Desmopressin impurity profile
Every named species the index has reported alongside Desmopressin, how often, at what level, and what its presence implies about the synthesis or the handling. Reporting threshold is 0.05 % area; anything below it is invisible to this page and is silently added to the main peak.
Median total impurities
0.54%
n=33
Median largest single
0.31%
n=33
Worst single observed
1.06%
n=33
Named species observed
4 / 4
n=4
| Named species | ΔRT (min) | Δ mass (Da) | Seen in | Median % area | Max % area |
|---|---|---|---|---|---|
| [L-Arg8]-diastereomer (vasopressin-like) | -0.18 | mass-identical | 97% | 0.08 | 0.36 |
| open-chain (reduced disulfide, +2 Da) | -0.54 | +2.016 | 91% | 0.10 | 1.06 |
| desmopressin dimer | +2.24 | +1066.411 | 85% | 0.12 | 0.43 |
| des-amino artefact (+16 Da) | -0.30 | +15.995 | 82% | 0.08 | 1.01 |
[L-Arg8]-diastereomer (vasopressin-like)
- Retention offset from the main peak
- -0.18 min on RG-2
- Mass difference
- mass-identical — chromatography only
- Reported in
- 32 of 33 records (97 %)
- Level when reported
- median 0.08 %, max 0.36 %
- Resolution requirement
- A gradient long enough to separate it. No mass spectrometer will.
open-chain (reduced disulfide, +2 Da)
- Retention offset from the main peak
- -0.54 min on RG-2
- Mass difference
- +2.016 Da
- Reported in
- 30 of 33 records (91 %)
- Level when reported
- median 0.10 %, max 1.06 %
- Resolution requirement
- Baseline-resolved on the reference method.
desmopressin dimer
- Retention offset from the main peak
- +2.24 min on RG-2
- Mass difference
- +1066.411 Da
- Reported in
- 28 of 33 records (85 %)
- Level when reported
- median 0.12 %, max 0.43 %
- Resolution requirement
- Baseline-resolved on the reference method.
des-amino artefact (+16 Da)
- Retention offset from the main peak
- -0.30 min on RG-2
- Mass difference
- +15.995 Da
- Reported in
- 27 of 33 records (82 %)
- Level when reported
- median 0.08 %, max 1.01 %
- Resolution requirement
- Baseline-resolved on the reference method.
Degradation pathways
Degradants are a handling finding rather than a synthesis finding. A lot that shipped clean and arrived oxidised tells you about the courier, not the chemist.
- disulfide reduction
- epimerisation at Arg8