GHRP-6 impurity profile
Every named species the index has reported alongside GHRP-6, how often, at what level, and what its presence implies about the synthesis or the handling. Reporting threshold is 0.05 % area; anything below it is invisible to this page and is silently added to the main peak.
Median total impurities
0.35%
n=169
Median largest single
0.19%
n=169
Worst single observed
1.46%
n=169
Named species observed
4 / 4
n=4
| Named species | ΔRT (min) | Δ mass (Da) | Seen in | Median % area | Max % area |
|---|---|---|---|---|---|
| [D-Trp]-epimer | -0.12 | mass-identical | 93% | 0.06 | 1.46 |
| oxidised Trp (+16 Da) | -0.34 | +15.995 | 85% | 0.09 | 0.88 |
| bis-oxidised Trp (+32 Da) | -0.58 | +31.990 | 76% | 0.06 | 1.35 |
| des-Lys (−128 Da) | -0.22 | -128.095 | 65% | 0.09 | 1.09 |
[D-Trp]-epimer
- Retention offset from the main peak
- -0.12 min on RG-2
- Mass difference
- mass-identical — chromatography only
- Reported in
- 157 of 169 records (93 %)
- Level when reported
- median 0.06 %, max 1.46 %
- Resolution requirement
- A gradient long enough to separate it. No mass spectrometer will.
oxidised Trp (+16 Da)
- Retention offset from the main peak
- -0.34 min on RG-2
- Mass difference
- +15.995 Da
- Reported in
- 144 of 169 records (85 %)
- Level when reported
- median 0.09 %, max 0.88 %
- Resolution requirement
- Baseline-resolved on the reference method.
bis-oxidised Trp (+32 Da)
- Retention offset from the main peak
- -0.58 min on RG-2
- Mass difference
- +31.990 Da
- Reported in
- 129 of 169 records (76 %)
- Level when reported
- median 0.06 %, max 1.35 %
- Resolution requirement
- Baseline-resolved on the reference method.
des-Lys (−128 Da)
- Retention offset from the main peak
- -0.22 min on RG-2
- Mass difference
- -128.095 Da
- Reported in
- 110 of 169 records (65 %)
- Level when reported
- median 0.09 %, max 1.09 %
- Resolution requirement
- Close-eluting — resolution below 1.2 is common and the peaks merge on short gradients.
Degradation pathways
Degradants are a handling finding rather than a synthesis finding. A lot that shipped clean and arrived oxidised tells you about the courier, not the chemist.
- double Trp oxidation — GHRP-6 has two, and both go
- C-terminal amide hydrolysis