AssayIndex
Incretin analogues and co-agonists

Mazdutide

IBI362 · LY3305677 · oxyntomodulin analogue · C226H352N50O70 · monoisotopic 4912.6408 Da. The index holds 33 assay reports on this compound across 6 batches from 5 suppliers.

33 reports6 batchesmedian 98.11 %index spec 96.5 %
Section 1

Analytical fingerprint

Hand-authored chemistry. These properties describe the substance and do not change when a record is added.

Mazdutide submissions to the index are almost entirely from two suppliers, so its per-supplier table is short and its aggregate median should not be read as a market figure. Analytically it behaves like a slightly less hydrophobic tirzepatide: 19.4 min, similar diastereomer problem, similar broad base. The useful check is the 4912.64 monoisotopic mass, which is 102 Da above tirzepatide and unambiguous. Where a submitted mazdutide report shows a mass matching tirzepatide within 20 ppm, the index reclassifies the record and links both — see the corrections log.

Molecular formula
C226H352N50O70
Monoisotopic mass
4912.6408Da
Average mass
4915.60Da
Residues
39
Nominal retention (RG-2, 30 min)
19.42min
Retention window
0.50min
Counter-ion as usually shipped
TFA
Typical label claims
4 mg · 6 mg · 9 mg · 10 mg
Analytical difficulty (index scale)
1.40 — hard
Purity is a defined quantity
YES
Section 2

Representative chromatogram

Drawn from this page's own medians. Not a scan, not an illustration, and not any single report.

01364272940935458 Mazdutide19.42 min · 98.11 % 17.6820.32 same trace · ×200 vertical expansion, baseline-corrected · main peak off-scale reporting threshold 0.05 % area 05101520253035 Retention time (min) Response (mAU)
Figure 1. A representative Mazdutide trace on the index reference method RG-2, constructed from this page's own numbers: the main peak carries the index median purity of 98.11 % area at the nominal retention time of 19.42 min, and each impurity peak carries the median area the index has observed for that named species at its characteristic retention offset. It is not a scan of any single report — every individual record's own chromatogram is on its own page. The lower panel is the same trace at a stated vertical expansion, baseline-corrected, so the impurities are visible; the main peak runs off-scale there by design. Baseline noise is seeded from the compound slug.
Section 3

What the index has observed

Arithmetic over the 33 records the index holds. Aggregates on this page are computed over the records the index holds, which are not a random sample of the material on the market. Lots that get tested are lots someone chose to test. Read every figure here as a description of this dataset rather than as an estimate of a population.

Median purity 98.11% n=33
Interquartile range 0.70pp n=33
Minimum 97.02% n=33
Maximum 99.93% n=33
Pass rate vs spec 100.0% n=33
Median recovery vs claim 97.0% n=19
Median water 3.51% n=33
Median |mass error| 2.2ppm n=24
036992.093.094.095.096.097.098.099.0100.092.00–92.25 %: n=092.25–92.50 %: n=092.50–92.75 %: n=092.75–93.00 %: n=093.00–93.25 %: n=093.25–93.50 %: n=093.50–93.75 %: n=093.75–94.00 %: n=094.00–94.25 %: n=094.25–94.50 %: n=094.50–94.75 %: n=094.75–95.00 %: n=095.00–95.25 %: n=095.25–95.50 %: n=095.50–95.75 %: n=095.75–96.00 %: n=096.00–96.25 %: n=096.25–96.50 %: n=096.50–96.75 %: n=096.75–97.00 %: n=097.00–97.25 %: n=197.25–97.50 %: n=497.50–97.75 %: n=197.75–98.00 %: n=998.00–98.25 %: n=298.25–98.50 %: n=698.50–98.75 %: n=498.75–99.00 %: n=299.00–99.25 %: n=299.25–99.50 %: n=199.50–99.75 %: n=099.75–100.00 %: n=1median 98.11 Purity (% area) Reports
Figure 2. Purity distribution across all 33 Mazdutide records. Dashed line is this compound's median (98.11 %); the solid vertical is the index acceptance specification for the incretin analogues and co-agonists class (96.5 %). Domain is fixed at 92–100 % on every purity histogram on this site so that compounds can be compared by eye — a wide distribution here is a hard compound, a narrow one is an easy one, and neither is a statement about the suppliers.
Section 4

By supplier

Suppliers with fewer than two purity records on this compound are omitted from the figure rather than drawn as a line. The full table, including the thin cells, is on the by-supplier page.

96.897.397.798.298.699.099.5SSASSA: Q1 97.94, median 98.29, Q3 98.74, n=17n=17SWBSWB: Q1 98.04, median 98.27, Q3 98.46, n=8n=8ERPERP: Q1 97.33, median 97.53, Q3 97.86, n=6n=6 Purity (% area)
Figure 3. Mazdutide purity by supplier, ordered by coverage. The vertical line is the index acceptance specification. Boxes that overlap are suppliers this dataset cannot separate, and most of them overlap.

Full per-supplier table with n= caveats →

Section 5

Characteristic impurities and degradants

The left three columns are authored chemistry — what this molecule characteristically carries and where it elutes. The right three are what the index has actually reported.

Named speciesΔRT (min, RG-2)Δ mass (Da)Seen inMedian % areaMax % area
[D-Aib2]-diastereomer-0.21mass-identical100%0.320.80
des-Aib2 analogue-0.39-85.053100%0.271.63
oxidised Met (+16 Da)-0.70+15.99597%0.171.28
truncated (4-39)-1.74-315.16997%0.311.25
trifluoroacetyl adduct (+96 Da)+0.90+95.98297%0.181.41

Degradation pathways

  • Met oxidation
  • lipid-chain hydrolysis under alkaline stress

Full impurity profile, with what each named species implies about the synthesis →

Section 6

Clinical context

Included because it is routinely misapplied. Trial data describes a licensed medicinal product manufactured under a marketing authorisation, and it does not transfer to research-grade material of unknown provenance.

Mazdutide's GLORY-1 phase 3 obesity results were reported in 2024; development is led in China, where it was approved in 2025.

Section 7

Quarterly coverage

QuarterReportsMedian purityRange
2024-Q10n<3—
2024-Q20n<3—
2024-Q30n<3—
2024-Q4897.8597.32–98.11
2025-Q10n<3—
2025-Q20n<3—
2025-Q31n<3—
2025-Q4898.2797.88–98.58
2026-Q10n<3—
2026-Q21698.4797.02–99.28
2026-Q30n<3—

Quarter-by-quarter detail →

Section 8

Most recent records

The 25 most recent Mazdutide records of 33.
ReportSupplierLotLabQuarterPurity %Water %Recovery %ProvenanceFlagsResult
AX-2026-042560ERPERP-2603-D7882VendorInvestigate2026-Q297.283.81104.1Buyer-sourced2MARGINAL
AX-2026-043117SSASSA-2605-G6781Janoshik2026-Q299.233.6790.4Supplier-supplied1MARGINAL
AX-2026-043118SSASSA-2605-G6781Medutest2026-Q298.292.6588.7Buyer-sourced2MARGINAL
AX-2026-042562ERPERP-2603-D7882Janoshik2026-Q297.464.39102.6Supplier-supplied2MARGINAL
AX-2026-042561ERPERP-2603-D7882PeptideMeter2026-Q297.944.0497.5Supplier-supplied2MARGINAL
AX-2026-043115SSASSA-2605-G6781PeptideMeter2026-Q298.452.4897.0Buyer-sourced1MARGINAL
AX-2026-043119SSASSA-2605-G6781Janoshik2026-Q299.282.75—Supplier-supplied1MARGINAL
AX-2026-043120SSASSA-2605-G6781PeptideMeter2026-Q298.743.24104.0Supplier-supplied1MARGINAL
AX-2026-043116SSASSA-2605-G6781Janoshik2026-Q298.652.63104.6Laboratory-retained1MARGINAL
AX-2026-043113SSASSA-2605-G6781Janoshik2026-Q298.492.68—Supplier-supplied1MARGINAL
AX-2026-043114SSASSA-2605-G6781Janoshik2026-Q299.023.41101.2Supplier-supplied1MARGINAL
AX-2026-042564ERPERP-2603-D7882Nordanalyt2026-Q297.614.26—Supplier-supplied2MARGINAL
AX-2026-042563ERPERP-2603-D7882PeptideMeter2026-Q297.953.9291.4Supplier-supplied2MARGINAL
AX-2026-042559ERPERP-2603-D7882PeptideMeter2026-Q297.023.3290.5Buyer-sourced2MARGINAL
AX-2026-043121SSASSA-2605-G6781Medutest2026-Q298.792.52—Supplier-supplied1MARGINAL
AX-2026-042889MKMMKM-2511-N2838Janoshik2026-Q298.767.0288.5Supplier-supplied3MARGINAL
AX-2025-019936SWBSWB-2505-Y5355Janoshik2025-Q498.103.0691.4Supplier-supplied1MARGINAL
AX-2025-019933SWBSWB-2505-Y5355Janoshik2025-Q498.572.95—Supplier-supplied1FAIL
AX-2025-019934SWBSWB-2505-Y5355Medutest2025-Q498.423.3597.1Supplier-supplied1FAIL
AX-2025-019935SWBSWB-2505-Y5355PeptideMeter2025-Q497.883.44—Buyer-sourced1MARGINAL
AX-2025-019931SWBSWB-2505-Y5355VendorInvestigate2025-Q498.282.90—Buyer-sourced1MARGINAL
AX-2025-019930SWBSWB-2505-Y5355Janoshik2025-Q498.253.37101.1Supplier-supplied1MARGINAL
AX-2025-019932SWBSWB-2505-Y5355Medutest2025-Q497.883.1790.2Supplier-supplied1MARGINAL
AX-2025-019937SWBSWB-2505-Y5355Medutest2025-Q498.583.51—Supplier-supplied1MARGINAL
AX-2025-018521WWBWWB-2503-Y3157Janoshik2025-Q399.936.1891.6Supplier-supplied1MARGINAL