N-Acetyl Semax Amide impurity profile
Every named species the index has reported alongside N-Acetyl Semax Amide, how often, at what level, and what its presence implies about the synthesis or the handling. Reporting threshold is 0.05 % area; anything below it is invisible to this page and is silently added to the main peak.
Median total impurities
0.74%
n=89
Median largest single
0.39%
n=89
Worst single observed
1.38%
n=89
Named species observed
4 / 4
n=4
| Named species | ΔRT (min) | Δ mass (Da) | Seen in | Median % area | Max % area |
|---|---|---|---|---|---|
| Met sulfoxide (+16 Da) | -0.34 | +15.995 | 98% | 0.13 | 1.36 |
| des-acetyl amide (−42 Da) | -0.40 | -42.011 | 92% | 0.12 | 0.69 |
| semax (des-acetyl, des-amide, −41 Da) | -0.56 | -41.027 | 84% | 0.14 | 0.83 |
| N-acetyl semax free acid (+1 Da) | +0.22 | +0.984 | 84% | 0.23 | 1.38 |
Met sulfoxide (+16 Da)
- Retention offset from the main peak
- -0.34 min on RG-2
- Mass difference
- +15.995 Da
- Reported in
- 87 of 89 records (98 %)
- Level when reported
- median 0.13 %, max 1.36 %
- Resolution requirement
- Baseline-resolved on the reference method.
des-acetyl amide (−42 Da)
- Retention offset from the main peak
- -0.40 min on RG-2
- Mass difference
- -42.011 Da
- Reported in
- 82 of 89 records (92 %)
- Level when reported
- median 0.12 %, max 0.69 %
- Resolution requirement
- Baseline-resolved on the reference method.
semax (des-acetyl, des-amide, −41 Da)
- Retention offset from the main peak
- -0.56 min on RG-2
- Mass difference
- -41.027 Da
- Reported in
- 75 of 89 records (84 %)
- Level when reported
- median 0.14 %, max 0.83 %
- Resolution requirement
- Baseline-resolved on the reference method.
N-acetyl semax free acid (+1 Da)
- Retention offset from the main peak
- +0.22 min on RG-2
- Mass difference
- +0.984 Da
- Reported in
- 75 of 89 records (84 %)
- Level when reported
- median 0.23 %, max 1.38 %
- Resolution requirement
- Close-eluting — resolution below 1.2 is common and the peaks merge on short gradients.
Degradation pathways
Degradants are a handling finding rather than a synthesis finding. A lot that shipped clean and arrived oxidised tells you about the courier, not the chemist.
- acetyl loss
- C-terminal amide hydrolysis
- Met oxidation