AssayIndex
Non-peptide adjuncts

5-Amino-1MQ

5-amino-1-methylquinolinium · 5-A-1MQ · C10H11N2+ · I− · monoisotopic 285.9967 Da. The index holds 68 assay reports on this compound across 13 batches from 9 suppliers.

68 reports13 batchesmedian 99.24 %index spec 98.0 %
Section 1

Analytical fingerprint

Hand-authored chemistry. These properties describe the substance and do not change when a record is added.

A quaternary quinolinium iodide salt. It is permanently charged, so it behaves badly on plain C18 and requires an ion-pairing additive; several submitted reports show no retention at all, which is a method finding rather than a material finding. The diagnostic impurity is the unreduced 5-nitro precursor at +30 Da, and levels above 1 % indicate an incomplete reduction step. Brown or yellow-tinged lots are almost always iodine from photolysis, and the index records appearance verbatim for that reason.

Compound class
Non-peptide adjuncts
Molecular formula
C10H11N2+ · I−
Monoisotopic mass
285.9967Da
Average mass
286.11Da
Residues
—
Nominal retention (RG-2, 30 min)
5.42min
Retention window
0.25min
Counter-ion as usually shipped
iodide
Typical label claims
50 mg · 100 mg
Analytical difficulty (index scale)
0.85 — straightforward
Purity is a defined quantity
YES
Section 2

Representative chromatogram

Drawn from this page's own medians. Not a scan, not an illustration, and not any single report.

0495199021485319804 5-Amino-1MQ5.42 min · 99.24 % 5.10 same trace · ×200 vertical expansion, baseline-corrected · main peak off-scale reporting threshold 0.05 % area 05101520253035 Retention time (min) Response (mAU)
Figure 1. A representative 5-Amino-1MQ trace on the index reference method RG-2, constructed from this page's own numbers: the main peak carries the index median purity of 99.24 % area at the nominal retention time of 5.42 min, and each impurity peak carries the median area the index has observed for that named species at its characteristic retention offset. It is not a scan of any single report — every individual record's own chromatogram is on its own page. The lower panel is the same trace at a stated vertical expansion, baseline-corrected, so the impurities are visible; the main peak runs off-scale there by design. Baseline noise is seeded from the compound slug.
Section 3

What the index has observed

Arithmetic over the 68 records the index holds. Aggregates on this page are computed over the records the index holds, which are not a random sample of the material on the market. Lots that get tested are lots someone chose to test. Read every figure here as a description of this dataset rather than as an estimate of a population.

Median purity 99.24% n=68
Interquartile range 0.69pp n=68
Minimum 97.95% n=68
Maximum 99.93% n=68
Pass rate vs spec 97.1% n=68
Median recovery vs claim 99.5% n=39
Median water 5.04% n=68
Median |mass error| 1.9ppm n=63
05101592.093.094.095.096.097.098.099.0100.092.00–92.25 %: n=092.25–92.50 %: n=092.50–92.75 %: n=092.75–93.00 %: n=093.00–93.25 %: n=093.25–93.50 %: n=093.50–93.75 %: n=093.75–94.00 %: n=094.00–94.25 %: n=094.25–94.50 %: n=094.50–94.75 %: n=094.75–95.00 %: n=095.00–95.25 %: n=095.25–95.50 %: n=095.50–95.75 %: n=095.75–96.00 %: n=096.00–96.25 %: n=096.25–96.50 %: n=096.50–96.75 %: n=096.75–97.00 %: n=097.00–97.25 %: n=097.25–97.50 %: n=097.50–97.75 %: n=097.75–98.00 %: n=298.00–98.25 %: n=198.25–98.50 %: n=398.50–98.75 %: n=598.75–99.00 %: n=1099.00–99.25 %: n=1599.25–99.50 %: n=1099.50–99.75 %: n=999.75–100.00 %: n=13median 99.24 Purity (% area) Reports
Figure 2. Purity distribution across all 68 5-Amino-1MQ records. Dashed line is this compound's median (99.24 %); the solid vertical is the index acceptance specification for the non-peptide adjuncts class (98.0 %). Domain is fixed at 92–100 % on every purity histogram on this site so that compounds can be compared by eye — a wide distribution here is a hard compound, a narrow one is an easy one, and neither is a statement about the suppliers.
Section 4

By supplier

Suppliers with fewer than two purity records on this compound are omitted from the figure rather than drawn as a line. The full table, including the thin cells, is on the by-supplier page.

97.898.298.698.999.399.7100.1MKMMKM: Q1 99.00, median 99.29, Q3 99.58, n=21n=21SWBSWB: Q1 99.06, median 99.28, Q3 99.60, n=12n=12WXTWXT: Q1 98.11, median 98.50, Q3 98.61, n=10n=10TFCTFC: Q1 99.08, median 99.43, Q3 99.81, n=9n=9QYBQYB: Q1 99.31, median 99.59, Q3 99.84, n=6n=6KPKP: Q1 98.89, median 99.33, Q3 99.45, n=5n=5GGPepsGGPeps: Q1 99.20, median 99.20, Q3 99.21, n=2n=2JEEPJEEP: Q1 99.62, median 99.72, Q3 99.83, n=2n=2 Purity (% area)
Figure 3. 5-Amino-1MQ purity by supplier, ordered by coverage. The vertical line is the index acceptance specification. Boxes that overlap are suppliers this dataset cannot separate, and most of them overlap.

Full per-supplier table with n= caveats →

Section 5

Characteristic impurities and degradants

The left three columns are authored chemistry — what this molecule characteristically carries and where it elutes. The right three are what the index has actually reported.

Named speciesΔRT (min, RG-2)Δ mass (Da)Seen inMedian % areaMax % area
5-nitro-1MQ (unreduced precursor, +30 Da)+0.68+29.97496%0.091.29
8-amino regioisomer+0.22mass-identical93%0.130.67
free iodide (counter-ion, by IC)0.00mass-identical93%0.130.56
1-methylquinolinium (des-amino, −15 Da)-0.32-15.01191%0.171.40

Degradation pathways

  • photodegradation of the quinolinium core
  • iodide oxidation to iodine on light exposure — visible browning

Full impurity profile, with what each named species implies about the synthesis →

Section 7

Quarterly coverage

QuarterReportsMedian purityRange
2024-Q10n<3—
2024-Q20n<3—
2024-Q30n<3—
2024-Q4499.0498.87–99.43
2025-Q10n<3—
2025-Q21998.7297.95–99.93
2025-Q32099.5598.77–99.93
2025-Q4799.0998.68–99.58
2026-Q11199.7699.13–99.93
2026-Q2799.2198.87–99.49
2026-Q30n<3—

Quarter-by-quarter detail →

Section 8

Most recent records

The 25 most recent 5-Amino-1MQ records of 68.
ReportSupplierLotLabQuarterPurity %Water %Recovery %ProvenanceFlagsResult
AX-2026-042753GGPepsGGPE-2512-M9695Medutest2026-Q299.214.6193.5Supplier-supplied2FAIL
AX-2026-042970KPKP-2511-W4792Janoshik2026-Q298.894.0391.0Supplier-supplied2FAIL
AX-2026-042969KPKP-2511-W4792Janoshik2026-Q299.333.94—Buyer-sourced2FAIL
AX-2026-042967KPKP-2511-W4792Janoshik2026-Q299.494.14—Supplier-supplied2FAIL
AX-2026-042754GGPepsGGPE-2512-M9695PeptideMeter2026-Q299.204.9096.8Supplier-supplied2FAIL
AX-2026-042971KPKP-2511-W4792Janoshik2026-Q299.454.19107.1Supplier-supplied2FAIL
AX-2026-042968KPKP-2511-W4792Janoshik2026-Q298.874.3291.5Buyer-sourced2FAIL
AX-2026-042012TFCTFC-2508-L6321Janoshik2026-Q199.935.8495.7Supplier-supplied0FAIL
AX-2026-042013TFCTFC-2508-L6321PeptideMeter2026-Q199.905.7890.3Supplier-supplied0FAIL
AX-2026-041541QYBQYB-2510-C6129Janoshik2026-Q199.273.46107.0Supplier-supplied1FAIL
AX-2026-042014TFCTFC-2508-L6321Janoshik2026-Q199.815.88—Supplier-supplied0FAIL
AX-2026-041543QYBQYB-2510-C6129Janoshik2026-Q199.873.59—Supplier-supplied0FAIL
AX-2026-042015TFCTFC-2508-L6321Nordanalyt2026-Q199.245.7396.3Buyer-sourced2FAIL
AX-2026-041540QYBQYB-2510-C6129Medutest2026-Q199.763.9795.0Supplier-supplied2FAIL
AX-2026-041544QYBQYB-2510-C6129Janoshik2026-Q199.133.53105.6Supplier-supplied1FAIL
AX-2026-041539QYBQYB-2510-C6129Medutest2026-Q199.933.62—Supplier-supplied0FAIL
AX-2026-042016TFCTFC-2508-L6321Medutest2026-Q199.575.37104.1Supplier-supplied2FAIL
AX-2026-042909MKMMKM-2506-T2989Kestrel2025-Q499.106.4699.9Supplier-supplied1FAIL
AX-2026-041542QYBQYB-2510-C6129Janoshik2026-Q199.433.5199.5Supplier-supplied1FAIL
AX-2026-042910MKMMKM-2506-T2989Medutest2025-Q498.996.67103.1Supplier-supplied1FAIL
AX-2025-020273MKMMKM-2506-T2989Janoshik2025-Q499.126.15—Supplier-supplied1FAIL
AX-2025-020275MKMMKM-2506-T2989Nordanalyt2025-Q498.686.5893.5Supplier-supplied1FAIL
AX-2025-020272MKMMKM-2506-T2989Janoshik2025-Q499.096.23—Supplier-supplied2FAIL
AX-2025-020274MKMMKM-2506-T2989Kestrel2025-Q499.586.0598.7Supplier-supplied2FAIL
AX-2025-020271MKMMKM-2506-T2989Janoshik2025-Q498.776.45—Supplier-supplied1FAIL