AssayIndex
Growth-hormone axis peptides

CJC-1295 with DAC

CJC-1295 DAC · drug affinity complex GRF · C165H269N47O46 · monoisotopic 3644.9748 Da. The index holds 136 assay reports on this compound across 24 batches from 13 suppliers.

136 reports24 batchesmedian 98.79 %index spec 97.5 %
Section 1

Analytical fingerprint

Hand-authored chemistry. These properties describe the substance and do not change when a record is added.

The DAC variant carries a maleimidopropionyl-lysine handle whose whole purpose is covalent albumin binding. That handle hydrolyses to an open maleamic acid at +18 Da, which is chromatographically resolved (0.62 min early) and functionally inert. The index therefore reports "intact maleimide fraction" as a separate figure from purity on CJC-1295 DAC records, because a lot can be 98 % pure and still be largely non-functional. Roughly a third of submitted DAC lots show hydrolysed maleimide above 3 % area, and that number is the single most useful thing in this compound's record set.

Molecular formula
C165H269N47O46
Monoisotopic mass
3644.9748Da
Average mass
3647.30Da
Residues
30
Nominal retention (RG-2, 30 min)
14.62min
Retention window
0.35min
Counter-ion as usually shipped
acetate
Typical label claims
2 mg · 5 mg · 10 mg
Analytical difficulty (index scale)
1.20 — moderate
Purity is a defined quantity
YES
Section 2

Representative chromatogram

Drawn from this page's own medians. Not a scan, not an illustration, and not any single report.

01825364954747299 CJC-1295 with DAC14.62 min · 98.79 % 14.0017.04 same trace · ×100 vertical expansion, baseline-corrected · main peak off-scale reporting threshold 0.05 % area 05101520253035 Retention time (min) Response (mAU)
Figure 1. A representative CJC-1295 with DAC trace on the index reference method RG-2, constructed from this page's own numbers: the main peak carries the index median purity of 98.79 % area at the nominal retention time of 14.62 min, and each impurity peak carries the median area the index has observed for that named species at its characteristic retention offset. It is not a scan of any single report — every individual record's own chromatogram is on its own page. The lower panel is the same trace at a stated vertical expansion, baseline-corrected, so the impurities are visible; the main peak runs off-scale there by design. Baseline noise is seeded from the compound slug.
Section 3

What the index has observed

Arithmetic over the 136 records the index holds. Aggregates on this page are computed over the records the index holds, which are not a random sample of the material on the market. Lots that get tested are lots someone chose to test. Read every figure here as a description of this dataset rather than as an estimate of a population.

Median purity 98.79% n=136
Interquartile range 1.04pp n=136
Minimum 96.67% n=136
Maximum 99.93% n=136
Pass rate vs spec 96.3% n=136
Median recovery vs claim 100.1% n=76
Median water 4.40% n=136
Median |mass error| 2.8ppm n=118
06121892.093.094.095.096.097.098.099.0100.092.00–92.25 %: n=092.25–92.50 %: n=092.50–92.75 %: n=092.75–93.00 %: n=093.00–93.25 %: n=093.25–93.50 %: n=093.50–93.75 %: n=093.75–94.00 %: n=094.00–94.25 %: n=094.25–94.50 %: n=094.50–94.75 %: n=094.75–95.00 %: n=095.00–95.25 %: n=095.25–95.50 %: n=095.50–95.75 %: n=095.75–96.00 %: n=096.00–96.25 %: n=096.25–96.50 %: n=096.50–96.75 %: n=196.75–97.00 %: n=197.00–97.25 %: n=297.25–97.50 %: n=197.50–97.75 %: n=397.75–98.00 %: n=698.00–98.25 %: n=2098.25–98.50 %: n=1498.50–98.75 %: n=1798.75–99.00 %: n=1199.00–99.25 %: n=2199.25–99.50 %: n=1899.50–99.75 %: n=799.75–100.00 %: n=14median 98.79 Purity (% area) Reports
Figure 2. Purity distribution across all 136 CJC-1295 with DAC records. Dashed line is this compound's median (98.79 %); the solid vertical is the index acceptance specification for the growth-hormone axis peptides class (97.5 %). Domain is fixed at 92–100 % on every purity histogram on this site so that compounds can be compared by eye — a wide distribution here is a hard compound, a narrow one is an easy one, and neither is a statement about the suppliers.
Section 4

By supplier

Suppliers with fewer than two purity records on this compound are omitted from the figure rather than drawn as a line. The full table, including the thin cells, is on the by-supplier page.

96.497.097.798.398.999.6100.2WWBWWB: Q1 99.19, median 99.37, Q3 99.53, n=26n=26QSCQSC: Q1 98.79, median 98.90, Q3 99.07, n=21outlier 98.14outlier 98.22outlier 98.27n=21BCHBCH: Q1 98.01, median 98.14, Q3 98.51, n=20n=20MKMMKM: Q1 98.36, median 98.73, Q3 99.18, n=13n=13JEEPJEEP: Q1 98.93, median 99.21, Q3 99.58, n=12n=12GGPepsGGPeps: Q1 97.72, median 98.00, Q3 98.20, n=12outlier 96.88n=12SGNSGN: Q1 98.33, median 98.42, Q3 98.77, n=8n=8ERPERP: Q1 99.04, median 99.52, Q3 99.92, n=7n=7SWBSWB: Q1 98.10, median 98.56, Q3 98.59, n=5n=5WXTWXT: Q1 96.92, median 97.53, Q3 98.11, n=4n=4KPKP: Q1 99.24, median 99.43, Q3 99.56, n=4n=4TFCTFC: Q1 98.76, median 98.85, Q3 98.95, n=2n=2SSASSA: Q1 98.02, median 98.04, Q3 98.06, n=2n=2 Purity (% area)
Figure 3. CJC-1295 with DAC purity by supplier, ordered by coverage. The vertical line is the index acceptance specification. Boxes that overlap are suppliers this dataset cannot separate, and most of them overlap.

Full per-supplier table with n= caveats →

Section 5

Characteristic impurities and degradants

The left three columns are authored chemistry — what this molecule characteristically carries and where it elutes. The right three are what the index has actually reported.

Named speciesΔRT (min, RG-2)Δ mass (Da)Seen inMedian % areaMax % area
hydrolysed maleimide (+18 Da)-0.62+18.01199%0.352.10
maleimide dimer+2.42+3644.97596%0.151.71
mod-GRF (1-29) (−279 Da)-1.76-279.23594%0.231.38
deamidated (+1 Da)-0.26+0.98493%0.161.53

Degradation pathways

  • maleimide ring hydrolysis to the unreactive maleamic acid — the defining stability problem
  • this hydrolysis is pH-driven and fast above pH 8

Full impurity profile, with what each named species implies about the synthesis →

Section 7

Quarterly coverage

QuarterReportsMedian purityRange
2024-Q10n<3—
2024-Q20n<3—
2024-Q30n<3—
2024-Q4398.5898.11–98.70
2025-Q11998.4196.67–99.34
2025-Q21n<3—
2025-Q31598.5897.78–99.80
2025-Q42299.2598.65–99.93
2026-Q15098.8496.88–99.93
2026-Q2898.7298.07–99.32
2026-Q31898.6297.39–99.43

Quarter-by-quarter detail →

Section 8

Most recent records

The 25 most recent CJC-1295 with DAC records of 136.
ReportSupplierLotLabQuarterPurity %Water %Recovery %ProvenanceFlagsResult
AX-2026-041727QSCQSC-2602-E9474Janoshik2026-Q398.886.62105.3Supplier-supplied1MARGINAL
AX-2026-041728QSCQSC-2602-E9474VendorInvestigate2026-Q398.427.04—Buyer-sourced1MARGINAL
AX-2026-041734QSCQSC-2602-E9474Medutest2026-Q399.437.17105.5Supplier-supplied2FAIL
AX-2026-043539BCHBCH-2607-H7307Janoshik2026-Q398.125.78100.6Supplier-supplied1MARGINAL
AX-2026-041730QSCQSC-2602-E9474PeptideMeter2026-Q398.796.9395.4Supplier-supplied1MARGINAL
AX-2026-041731QSCQSC-2602-E9474VendorInvestigate2026-Q399.077.1899.6Buyer-sourced1MARGINAL
AX-2026-041725QSCQSC-2602-E9474Medutest2026-Q399.067.04107.3Supplier-supplied2FAIL
AX-2026-043537BCHBCH-2607-H7307Janoshik2026-Q398.455.49103.1Supplier-supplied1MARGINAL
AX-2026-041726QSCQSC-2602-E9474Janoshik2026-Q399.157.01—Supplier-supplied1MARGINAL
AX-2026-043535BCHBCH-2607-H7307Janoshik2026-Q397.565.31107.4Laboratory-retained1MARGINAL
AX-2026-041732QSCQSC-2602-E9474Janoshik2026-Q398.406.85101.8Supplier-supplied1MARGINAL
AX-2026-043538BCHBCH-2607-H7307Janoshik2026-Q397.925.97—Supplier-supplied1MARGINAL
AX-2026-043536BCHBCH-2607-H7307Janoshik2026-Q398.075.67103.6Supplier-supplied1MARGINAL
AX-2026-043540BCHBCH-2607-H7307Medutest2026-Q397.395.68101.9Supplier-supplied1FAIL
AX-2026-043534BCHBCH-2607-H7307Medutest2026-Q397.925.81104.7Supplier-supplied2FAIL
AX-2026-041735QSCQSC-2602-E9474Janoshik2026-Q399.066.76—Supplier-supplied1MARGINAL
AX-2026-041733QSCQSC-2602-E9474Janoshik2026-Q399.006.5096.2Supplier-supplied1FAIL
AX-2026-041729QSCQSC-2602-E9474Nordanalyt2026-Q399.277.23104.7Supplier-supplied1MARGINAL
AX-2026-042066TFCTFC-2605-P7517Janoshik2026-Q298.666.04—Supplier-supplied1MARGINAL
AX-2026-042424SWBSWB-2511-Y5187Janoshik2026-Q298.724.15103.5Supplier-supplied2MARGINAL
AX-2026-043395WXTWXT-2602-F3755Nordanalyt2026-Q298.244.3589.6Supplier-supplied2MARGINAL
AX-2026-042065TFCTFC-2605-P7517Medutest2026-Q299.055.8192.9Buyer-sourced0PASS
AX-2026-041912JEEPJEEP-2602-R4187Janoshik2026-Q299.004.9195.0Supplier-supplied1MARGINAL
AX-2026-041911JEEPJEEP-2602-R4187Medutest2026-Q298.734.24—Laboratory-retained1MARGINAL
AX-2026-041913JEEPJEEP-2602-R4187PeptideMeter2026-Q299.324.1697.1Supplier-supplied1MARGINAL