Ipamorelin impurity profile
Every named species the index has reported alongside Ipamorelin, how often, at what level, and what its presence implies about the synthesis or the handling. Reporting threshold is 0.05 % area; anything below it is invisible to this page and is silently added to the main peak.
Median total impurities
0.52%
n=223
Median largest single
0.29%
n=223
Worst single observed
1.58%
n=223
Named species observed
5 / 5
n=5
| Named species | ΔRT (min) | Δ mass (Da) | Seen in | Median % area | Max % area |
|---|---|---|---|---|---|
| des-Lys (−128 Da) | -0.22 | -128.095 | 91% | 0.06 | 1.58 |
| oxidised Trp (+16 Da) | -0.34 | +15.995 | 78% | 0.12 | 1.37 |
| C-terminal free acid (+1 Da) | +0.18 | +0.984 | 76% | 0.07 | 1.16 |
| [D-Trp]-epimer | -0.12 | mass-identical | 70% | 0.06 | 1.42 |
| Aib-deletion sequence (−85 Da) | -0.28 | -85.053 | 65% | 0.08 | 1.49 |
des-Lys (−128 Da)
- Retention offset from the main peak
- -0.22 min on RG-2
- Mass difference
- -128.095 Da
- Reported in
- 204 of 223 records (91 %)
- Level when reported
- median 0.06 %, max 1.58 %
- Resolution requirement
- Close-eluting — resolution below 1.2 is common and the peaks merge on short gradients.
oxidised Trp (+16 Da)
- Retention offset from the main peak
- -0.34 min on RG-2
- Mass difference
- +15.995 Da
- Reported in
- 173 of 223 records (78 %)
- Level when reported
- median 0.12 %, max 1.37 %
- Resolution requirement
- Baseline-resolved on the reference method.
C-terminal free acid (+1 Da)
- Retention offset from the main peak
- +0.18 min on RG-2
- Mass difference
- +0.984 Da
- Reported in
- 169 of 223 records (76 %)
- Level when reported
- median 0.07 %, max 1.16 %
- Resolution requirement
- Close-eluting — resolution below 1.2 is common and the peaks merge on short gradients.
[D-Trp]-epimer
- Retention offset from the main peak
- -0.12 min on RG-2
- Mass difference
- mass-identical — chromatography only
- Reported in
- 155 of 223 records (70 %)
- Level when reported
- median 0.06 %, max 1.42 %
- Resolution requirement
- A gradient long enough to separate it. No mass spectrometer will.
Aib-deletion sequence (−85 Da)
- Retention offset from the main peak
- -0.28 min on RG-2
- Mass difference
- -85.053 Da
- Reported in
- 146 of 223 records (65 %)
- Level when reported
- median 0.08 %, max 1.49 %
- Resolution requirement
- Close-eluting — resolution below 1.2 is common and the peaks merge on short gradients.
Degradation pathways
Degradants are a handling finding rather than a synthesis finding. A lot that shipped clean and arrived oxidised tells you about the courier, not the chemist.
- Trp oxidation on light exposure
- C-terminal amide hydrolysis