AssayIndex

QSC-2508-F9226

Semaglutide · 3 mg declared · Qingdao Sigma Chemical Co., Ltd. · manufactured 22 Aug 2025

CHARACTERISED
Lot code
QSC-2508-F9226
Supplier
QSC — Qingdao Sigma Chemical Co., Ltd.
Compound
Semaglutide
Compound class
Incretin analogues and co-agonists
Declared label claim
3mg
Manufacture date
22 Aug 2025
Index quarter
2026-Q1
Independent assays
10
Laboratories involved
Kestrel, Medutest, VendorInvestigate, PeptideMeter, Janoshik
Provenance mix
Buyer-sourced ×2 · Supplier-supplied ×8
Section 1

Reproducibility across independent tests

Every report below is an observation of the same physical material. What they disagree about is measurement; what they agree about is the lot. The size of the disagreement is compared against what the contributing laboratories' own repeatability figures predict.

Independent assays 10
Median purity 99.37% n=10
Spread (max − min) 1.26pp n=10
Standard deviation 0.460pp n=10
96.196.897.598.298.899.5100.2This lot (QSC-2508-F9226)This lot (QSC-2508-F9226): Q1 99.03, median 99.37, Q3 99.78, n=10n=10All SemaglutideAll Semaglutide: Q1 98.24, median 98.87, Q3 99.33, n=926outlier 96.37n=926 Purity (% area)
Figure 1. This lot's independent purity results against the whole Semaglutide record set in the index. The vertical line is the index acceptance specification for the incretin analogues and co-agonists class, 97.0 % area. A narrow box on the top row against a wide box on the bottom row is the ideal reading: it means the disagreement between lots is much larger than the disagreement within this one.
Section 2

Member reports 10

Every report the index holds on this lot. Each is a page carrying its own chromatogram, mass spectrum, mass balance, provenance and caveats.

ReportLotLabQuarterPurity %Water %Recovery %ProvenanceFlagsResult
AX-2026-041687QSC-2508-F9226Kestrel2026-Q199.935.35103.6Supplier-supplied2FAIL
AX-2026-041688QSC-2508-F9226Medutest2026-Q199.744.73—Supplier-supplied2MARGINAL
AX-2026-041689QSC-2508-F9226VendorInvestigate2026-Q198.675.34—Buyer-sourced1MARGINAL
AX-2026-041690QSC-2508-F9226PeptideMeter2026-Q199.374.87—Supplier-supplied2MARGINAL
AX-2026-041691QSC-2508-F9226Janoshik2026-Q199.295.74102.8Supplier-supplied1MARGINAL
AX-2026-041692QSC-2508-F9226VendorInvestigate2026-Q198.805.26—Buyer-sourced1MARGINAL
AX-2026-041693QSC-2508-F9226Janoshik2026-Q199.884.9393.0Supplier-supplied1MARGINAL
AX-2026-041694QSC-2508-F9226PeptideMeter2026-Q199.364.50—Supplier-supplied2MARGINAL
AX-2026-041695QSC-2508-F9226Janoshik2026-Q199.804.83—Supplier-supplied1MARGINAL
AX-2026-041696QSC-2508-F9226Janoshik2026-Q198.944.92—Supplier-supplied2MARGINAL
Section 3

By laboratory

Where more than one laboratory assayed this lot, the difference between them is a paired observation of their relative bias — the same material, the same time window, different instruments. Those pairs are what the index's bias estimates are built from.

LaboratoryReportsPurity results (% area)MedianGradientPublished bias (pp)Bias-adjusted
Kestrel199.9399.9315min+0.2499.69
Medutest199.7499.7425min+0.0899.66
VendorInvestigate298.67, 98.8098.7332min-0.1198.84
PeptideMeter299.37, 99.3699.3728min-0.0599.42
Janoshik499.29, 99.88, 99.80, 98.9499.5530min+0.0099.55

This lot contributes 10 paired comparisons to the inter-lab analysis.

Section 4

The supplier's certificate for this lot

One number the supplier wrote, beside the median of the numbers other people measured on the same physical material. That comparison is only available because the index groups by lot.

FigureSupplier COAThis reportIndex note
Purity (% area)99.9099.93divergence +0.53 pp vs batch median
Total impurities (% area)not stated0.07
Largest single impurity (% area)not stated0.05
Water (%)not stated5.35
Counter-ion (%)3.19.30
Peptide content (%w/w)92.885.19
Endotoxin (EU/mg)not statednot determined
Method stated on certificateNO—no method section — the result cannot be reconciled against any other
Section 5

Impurity fingerprint

The named impurities reported across this lot's assays, with how consistently each was seen. A fingerprint is what allows two lot numbers held by different companies to be identified as one bulk.

Named impurityReported inMedian % areaRange
deamidated (Asn→Asp, +1 Da)10 / 100.290.05–0.92
des-His1 truncate (−137 Da)9 / 100.030.01–0.10
[D-Aib8]-diastereomer6 / 100.170.02–0.43
Met(O) sulfoxide (+16 Da)5 / 100.040.02–0.20
des-AEEA semaglutide (−145 Da)5 / 100.120.03–0.20
semaglutide dimer4 / 100.020.02–0.04
C18 diacid mono-ester3 / 100.030.02–0.03
tBu-protected residual (+56 Da)2 / 100.040.02–0.07
Section 7

What this rollup does not establish