QSC-2511-M8856

Semaglutide · 10 mg declared · Qingdao Sigma Chemical Co., Ltd. · manufactured 20 Nov 2025

CHARACTERISED

Lot code: QSC-2511-M8856
Supplier: QSC — Qingdao Sigma Chemical Co., Ltd.
Compound: Semaglutide
Compound class: Incretin analogues and co-agonists
Declared label claim: 10mg
Manufacture date: 20 Nov 2025
Index quarter: 2026-Q2
Independent assays: 15
Laboratories involved: Medutest, Janoshik, Nordanalyt, VendorInvestigate, PeptideMeter, Kestrel
Provenance mix: Buyer-sourced ×14 · Supplier-supplied ×1

Section 1

Reproducibility across independent tests

Every report below is an observation of the same physical material. What they disagree about is measurement; what they agree about is the lot. The size of the disagreement is compared against what the contributing laboratories' own repeatability figures predict.

Independent assays 15

Median purity 99.42% n=15

Spread (max − min) 1.22pp n=15

Standard deviation 0.313pp n=15

Figure 1. This lot's independent purity results against the whole Semaglutide record set in the index. The vertical line is the index acceptance specification for the incretin analogues and co-agonists class, 97.0 % area. A narrow box on the top row against a wide box on the bottom row is the ideal reading: it means the disagreement between lots is much larger than the disagreement within this one.

Section 2

Member reports 15

Every report the index holds on this lot. Each is a page carrying its own chromatogram, mass spectrum, mass balance, provenance and caveats.

Report	Lot	Lab	Quarter	Purity %	Water %	Recovery %	Provenance	Flags	Result
AX-2026-041678	QSC-2511-M8856	Medutest	2026-Q2	99.59	3.51	—	Supplier-supplied	2	MARGINAL
AX-2026-041679	QSC-2511-M8856	Janoshik	2026-Q2	99.22	3.73	90.8	Buyer-sourced	2	MARGINAL
AX-2026-041680	QSC-2511-M8856	Janoshik	2026-Q2	99.51	3.21	102.9	Buyer-sourced	2	MARGINAL
AX-2026-041681	QSC-2511-M8856	Nordanalyt	2026-Q2	99.63	4.18	105.7	Buyer-sourced	2	MARGINAL
AX-2026-041682	QSC-2511-M8856	Janoshik	2026-Q2	99.22	3.56	96.2	Buyer-sourced	2	MARGINAL
AX-2026-041683	QSC-2511-M8856	VendorInvestigate	2026-Q2	99.00	3.66	106.3	Buyer-sourced	2	MARGINAL
AX-2026-041684	QSC-2511-M8856	PeptideMeter	2026-Q2	99.42	3.42	106.0	Buyer-sourced	2	MARGINAL
AX-2026-041685	QSC-2511-M8856	Janoshik	2026-Q2	99.08	3.31	90.5	Buyer-sourced	2	MARGINAL
AX-2026-041686	QSC-2511-M8856	PeptideMeter	2026-Q2	99.14	3.73	—	Buyer-sourced	2	MARGINAL
AX-2026-041687	QSC-2511-M8856	Kestrel	2026-Q2	99.40	3.68	101.0	Buyer-sourced	2	MARGINAL
AX-2026-041688	QSC-2511-M8856	Medutest	2026-Q2	99.69	3.54	91.7	Buyer-sourced	2	MARGINAL
AX-2026-041689	QSC-2511-M8856	VendorInvestigate	2026-Q2	98.66	3.58	—	Buyer-sourced	2	MARGINAL
AX-2026-041690	QSC-2511-M8856	Janoshik	2026-Q2	99.52	3.15	—	Buyer-sourced	2	MARGINAL
AX-2026-041691	QSC-2511-M8856	Janoshik	2026-Q2	99.54	3.91	89.0	Buyer-sourced	3	MARGINAL
AX-2026-041692	QSC-2511-M8856	PeptideMeter	2026-Q2	99.88	3.60	106.0	Buyer-sourced	2	MARGINAL

Section 3

By laboratory

Where more than one laboratory assayed this lot, the difference between them is a paired observation of their relative bias — the same material, the same time window, different instruments. Those pairs are what the index's bias estimates are built from.

Laboratory	Reports	Purity results (% area)	Median	Gradient	Published bias (pp)	Bias-adjusted
Medutest	2	99.59, 99.69	99.64	25min	+0.08	99.56
Janoshik	6	99.22, 99.51, 99.22, 99.08, 99.52, 99.54	99.37	30min	+0.00	99.37
Nordanalyt	1	99.63	99.63	35min	+0.02	99.61
VendorInvestigate	2	99.00, 98.66	98.83	32min	-0.11	98.94
PeptideMeter	3	99.42, 99.14, 99.88	99.42	28min	-0.05	99.47
Kestrel	1	99.40	99.40	15min	+0.24	99.16

This lot contributes 15 paired comparisons to the inter-lab analysis.

Section 4

The supplier's certificate for this lot

One number the supplier wrote, beside the median of the numbers other people measured on the same physical material. That comparison is only available because the index groups by lot.

Figure	Supplier COA	This report	Index note
Purity (% area)	99.42	99.59	divergence 0.00 pp vs batch median
Total impurities (% area)	0.33	0.41
Largest single impurity (% area)	0.58	0.17
Water (%)	2.1	3.51
Counter-ion (%)	3.2	10.99
Peptide content (%w/w)	94.1	not determined
Endotoxin (EU/mg)	0.54	1.18
Method stated on certificate	YES	—	column, gradient and wavelength given

Section 5

Impurity fingerprint

The named impurities reported across this lot's assays, with how consistently each was seen. A fingerprint is what allows two lot numbers held by different companies to be identified as one bulk.

Named impurity	Reported in	Median % area	Range
[D-Aib8]-diastereomer	15 / 15	0.17	0.02–0.25
des-AEEA semaglutide (−145 Da)	15 / 15	0.33	0.08–0.89
Met(O) sulfoxide (+16 Da)	12 / 15	0.04	0.02–0.06
deamidated (Asn→Asp, +1 Da)	9 / 15	0.04	0.02–0.15
C18 diacid mono-ester	8 / 15	0.05	0.02–0.06
des-His1 truncate (−137 Da)	7 / 15	0.03	0.01–0.06
semaglutide dimer	1 / 15	0.02	—

Section 7

Reproducibility across independent tests

Member reports 15

By laboratory

The supplier's certificate for this lot

Impurity fingerprint

What this rollup does not establish