AssayIndex
Non-peptide adjuncts

Enclomiphene citrate

enclomiphene · trans-clomiphene · C26H28ClNO · C6H8O7 · monoisotopic 597.2130 Da. The index holds 55 assay reports on this compound across 12 batches from 9 suppliers.

55 reports12 batchesmedian 99.23 %index spec 98.5 %
Section 1

Analytical fingerprint

Hand-authored chemistry. These properties describe the substance and do not change when a record is added.

Enclomiphene is the trans isomer of clomiphene, and its whole reason for existing is not being the cis isomer. Zuclomiphene is mass-identical and elutes 0.62 min early; isomeric purity is therefore the only meaningful purity figure and it requires a validated isomer-resolving method. Of 68 enclomiphene reports in the index, 24 state an isomer ratio. The remaining 44 report a total purity that is compatible with a 50:50 clomiphene mixture, and the index says so on each of them. This is the clearest case in the whole dataset of a number that looks like evidence and is not.

Compound class
Non-peptide adjuncts
Molecular formula
C26H28ClNO · C6H8O7
Monoisotopic mass
597.2130Da
Average mass
598.08Da
Residues
—
Nominal retention (RG-2, 30 min)
16.44min
Retention window
0.35min
Counter-ion as usually shipped
citrate
Typical label claims
12.5 mg · 25 mg · 50 mg
Analytical difficulty (index scale)
0.90 — straightforward
Purity is a defined quantity
YES
Section 2

Representative chromatogram

Drawn from this page's own medians. Not a scan, not an illustration, and not any single report.

01632326348956527 Enclomiphene citrate16.44 min · 99.23 % 16.00 same trace · ×200 vertical expansion, baseline-corrected · main peak off-scale reporting threshold 0.05 % area 05101520253035 Retention time (min) Response (mAU)
Figure 1. A representative Enclomiphene citrate trace on the index reference method RG-2, constructed from this page's own numbers: the main peak carries the index median purity of 99.23 % area at the nominal retention time of 16.44 min, and each impurity peak carries the median area the index has observed for that named species at its characteristic retention offset. It is not a scan of any single report — every individual record's own chromatogram is on its own page. The lower panel is the same trace at a stated vertical expansion, baseline-corrected, so the impurities are visible; the main peak runs off-scale there by design. Baseline noise is seeded from the compound slug.
Section 3

What the index has observed

Arithmetic over the 55 records the index holds. Aggregates on this page are computed over the records the index holds, which are not a random sample of the material on the market. Lots that get tested are lots someone chose to test. Read every figure here as a description of this dataset rather than as an estimate of a population.

Median purity 99.23% n=55
Interquartile range 1.48pp n=55
Minimum 97.48% n=55
Maximum 99.93% n=55
Pass rate vs spec 67.3% n=55
Median recovery vs claim 96.8% n=29
Median water 4.56% n=55
Median |mass error| 2.5ppm n=45
0481292.093.094.095.096.097.098.099.0100.092.00–92.25 %: n=092.25–92.50 %: n=092.50–92.75 %: n=092.75–93.00 %: n=093.00–93.25 %: n=093.25–93.50 %: n=093.50–93.75 %: n=093.75–94.00 %: n=094.00–94.25 %: n=094.25–94.50 %: n=094.50–94.75 %: n=094.75–95.00 %: n=095.00–95.25 %: n=095.25–95.50 %: n=095.50–95.75 %: n=095.75–96.00 %: n=096.00–96.25 %: n=096.25–96.50 %: n=096.50–96.75 %: n=096.75–97.00 %: n=097.00–97.25 %: n=097.25–97.50 %: n=197.50–97.75 %: n=197.75–98.00 %: n=798.00–98.25 %: n=498.25–98.50 %: n=598.50–98.75 %: n=598.75–99.00 %: n=199.00–99.25 %: n=499.25–99.50 %: n=699.50–99.75 %: n=799.75–100.00 %: n=14median 99.23 Purity (% area) Reports
Figure 2. Purity distribution across all 55 Enclomiphene citrate records. Dashed line is this compound's median (99.23 %); the solid vertical is the index acceptance specification for the non-peptide adjuncts class (98.5 %). Domain is fixed at 92–100 % on every purity histogram on this site so that compounds can be compared by eye — a wide distribution here is a hard compound, a narrow one is an easy one, and neither is a statement about the suppliers.
Section 4

By supplier

Suppliers with fewer than two purity records on this compound are omitted from the figure rather than drawn as a line. The full table, including the thin cells, is on the by-supplier page.

97.397.898.298.799.299.7100.1GGPepsGGPeps: Q1 98.32, median 99.09, Q3 99.90, n=14n=14TFCTFC: Q1 99.20, median 99.36, Q3 99.67, n=8n=8QYBQYB: Q1 99.31, median 99.66, Q3 99.89, n=8n=8MKMMKM: Q1 97.94, median 98.03, Q3 98.11, n=8outlier 97.48n=8CPCCPC: Q1 98.28, median 98.57, Q3 98.66, n=7outlier 99.32n=7QSCQSC: Q1 99.59, median 99.91, Q3 99.93, n=5n=5SSASSA: Q1 97.78, median 97.83, Q3 97.87, n=2n=2SWBSWB: Q1 99.66, median 99.68, Q3 99.70, n=2n=2 Purity (% area)
Figure 3. Enclomiphene citrate purity by supplier, ordered by coverage. The vertical line is the index acceptance specification. Boxes that overlap are suppliers this dataset cannot separate, and most of them overlap.

Full per-supplier table with n= caveats →

Section 5

Characteristic impurities and degradants

The left three columns are authored chemistry — what this molecule characteristically carries and where it elutes. The right three are what the index has actually reported.

Named speciesΔRT (min, RG-2)Δ mass (Da)Seen inMedian % areaMax % area
zuclomiphene (cis-isomer)-0.62mass-identical96%0.121.41
N-oxide (+16 Da)-0.88+15.99596%0.111.28
des-ethyl enclomiphene (−28 Da)-0.44-28.03184%0.181.40
free base (des-citrate)+0.02-192.02780%0.111.53

Degradation pathways

  • cis/trans photoisomerisation — the compound isomerises in light back toward the clomiphene mixture
  • N-oxidation

Full impurity profile, with what each named species implies about the synthesis →

Section 7

Quarterly coverage

QuarterReportsMedian purityRange
2024-Q10n<3—
2024-Q20n<3—
2024-Q3399.5899.18–99.93
2024-Q42n<399.64–99.72
2025-Q11598.0397.48–98.63
2025-Q2499.7599.26–99.93
2025-Q3898.6097.91–99.32
2025-Q4799.9399.54–99.93
2026-Q1899.6699.15–99.93
2026-Q2899.2697.73–99.93
2026-Q30n<3—

Quarter-by-quarter detail →

Section 8

Most recent records

The 25 most recent Enclomiphene citrate records of 55.
ReportSupplierLotLabQuarterPurity %Water %Recovery %ProvenanceFlagsResult
AX-2026-043146SSASSA-2603-C6950Medutest2026-Q297.923.1192.9Buyer-sourced2FAIL
AX-2026-042041TFCTFC-2605-H7009Nordanalyt2026-Q299.403.99103.7Supplier-supplied1FAIL
AX-2026-042042TFCTFC-2605-H7009Kestrel2026-Q299.324.7189.9Supplier-supplied2FAIL
AX-2026-043145SSASSA-2603-C6950VendorInvestigate2026-Q297.733.64—Buyer-sourced2FAIL
AX-2026-041604QSCQSC-2604-R7865Janoshik2026-Q299.934.22—Supplier-supplied0FAIL
AX-2026-042040TFCTFC-2605-H7009Janoshik2026-Q299.934.5797.2Supplier-supplied0FAIL
AX-2026-042043TFCTFC-2605-H7009PeptideMeter2026-Q299.213.98—Supplier-supplied1FAIL
AX-2026-042044TFCTFC-2605-H7009Janoshik2026-Q298.844.60—Supplier-supplied1FAIL
AX-2026-041509QYBQYB-2603-A6476Medutest2026-Q199.934.69102.8Laboratory-retained0FAIL
AX-2026-041513QYBQYB-2603-A6476PeptideMeter2026-Q199.564.68—Supplier-supplied1FAIL
AX-2026-041507QYBQYB-2603-A6476PeptideMeter2026-Q199.154.46—Supplier-supplied1FAIL
AX-2026-041510QYBQYB-2603-A6476Medutest2026-Q199.764.7596.8Supplier-supplied0FAIL
AX-2026-041506QYBQYB-2603-A6476Nordanalyt2026-Q199.334.53—Supplier-supplied1FAIL
AX-2026-041511QYBQYB-2603-A6476Medutest2026-Q199.934.45—Supplier-supplied0FAIL
AX-2026-041512QYBQYB-2603-A6476Janoshik2026-Q199.235.11—Supplier-supplied1FAIL
AX-2026-041508QYBQYB-2603-A6476Medutest2026-Q199.884.56—Supplier-supplied0FAIL
AX-2025-020200GGPepsGGPE-2510-H1237Medutest2025-Q499.805.67—Buyer-sourced1FAIL
AX-2025-020205GGPepsGGPE-2510-H1237VendorInvestigate2025-Q499.545.16—Buyer-sourced1FAIL
AX-2025-020204GGPepsGGPE-2510-H1237Medutest2025-Q499.935.3094.7Supplier-supplied2FAIL
AX-2025-020203GGPepsGGPE-2510-H1237Janoshik2025-Q499.935.6596.8Supplier-supplied0FAIL
AX-2025-020202GGPepsGGPE-2510-H1237Janoshik2025-Q499.935.07101.6Supplier-supplied1FAIL
AX-2025-020201GGPepsGGPE-2510-H1237Janoshik2025-Q499.936.0793.9Supplier-supplied0FAIL
AX-2025-020206GGPepsGGPE-2510-H1237Janoshik2025-Q499.745.2599.1Supplier-supplied1FAIL
AX-2025-020993CPCCPC-2505-Y3713Janoshik2025-Q399.326.52—Supplier-supplied2FAIL
AX-2025-020992CPCCPC-2505-Y3713PeptideMeter2025-Q398.276.05107.4Supplier-supplied2FAIL