Cross-section

Pemvidutide by laboratory

The same compound measured by different laboratories on different gradients. Where the medians differ, the question is whether the material differed or the method did — and for Pemvidutide, with a class minimum gradient of 25 min, the method is a live explanation.

35 recordsmedian 98.41 %spec 96.0 %

Laboratory	Reports	Gradient	MS resolution	Median purity %	Published bias (pp)	Bias-adjusted	Method suitability
Janoshik	15	30min	High	98.42	+0.00	98.42	ADEQUATE
PeptideMeter	6 n=6	28min	High	98.41	-0.05	98.45	ADEQUATE
Medutest	5 n=5	25min	Unit	97.98	+0.08	97.90	ADEQUATE
VendorInvestigate	3 n=3	32min	High	97.31	-0.11	97.42	ADEQUATE
Nordanalyt	3 n=3	35min	High	98.51	+0.02	98.49	ADEQUATE
Kestrel	3 n=3	15min	Unit	99.08	+0.24	98.84	BELOW CLASS MINIMUM

Figure. Pemvidutide purity by contributing laboratory. Any offset between rows has two possible sources — a real difference in the material each laboratory happened to receive, and the laboratory's own bias — and this figure cannot separate them. The paired analysis that can is on inter-lab agreement.