AX-2026-043562

GHRP-6 · 5 mg declared · Bachem Holding (Suzhou) Co., Ltd. · lot BCH-2603-Y7018

FAILVERIFIED

Report ID: AX-2026-043562
Compound: GHRP-6
Compound class: Growth-hormone axis peptides
Supplier: BCH — Bachem Holding (Suzhou) Co., Ltd.
Batch / lot: BCH-2603-Y7018
Declared label claim: 5mg
Laboratory: PeptideMeter
Assay date: 30 May 2026
Submitted: 02 Jun 2026
Quarter: 2026-Q2
Submitter: h.nascimento
Sample provenance: Supplier-supplied

Section 1

Results

Measured against the index acceptance specification for the growth-hormone axis peptides class. A specification is a decision the index made; a result is a measurement. See where each threshold came from.

Parameter	Method	Result	Unit	Index spec
Purity	RP-HPLC, 28 min gradient, 214 nm	98.57	% area	≥ 99.0	FAIL
Total impurities	RP-HPLC, sum of reported peaks	1.43	% area	≤ 1.0	FAIL
Largest single impurity	RP-HPLC — bis-oxidised Trp (+32 Da)	0.91	% area	≤ 1.00	PASS
Identity — theoretical monoisotopic mass	calculated from molecular formula	872.4446	Da	—	NOT TESTED
Identity — observed monoisotopic mass	LC-MS, high resolution (ESI-TOF/QTOF)	872.4411	Da	—	NOT TESTED
Mass accuracy	observed vs theoretical	-4.0	ppm	± 15	PASS
Total peptide content	by difference from the gravimetric mass balance	89.99	%w/w	—	NOT TESTED
Target-compound content	total peptide content × purity	88.70	%w/w	—	NOT TESTED
Gross fill (as weighed)	five-place balance, under nitrogen	5.52	mg	5 mg declared	NOT TESTED
Recovered target peptide	gross fill × target content	4.896	mg	5 mg claim	NOT TESTED
Recovery against label claim	recovered ÷ claim	97.9	%	90.0 – 110.0	PASS
Water content	Karl Fischer, coulometric, duplicate	4.52	%	≤ 9.0	PASS
Counter-ion (acetate)	anion-exchange ion chromatography	4.69	%	≤ 12.0	PASS
Residual solvent + inorganic residue	estimated — see /methods/residual-solvents-q3c/	0.80	%	—	NOT TESTED
Endotoxin	kinetic chromogenic LAL	0.46	EU/mg	≤ 5.0	PASS
Sterility	membrane filtration, USP <71>, 14 d	No growth at 14 d	—	no growth	PASS
Appearance	visual, diffuse light, black and white background	White lyophilised cake, intact	—	white to off-white intact cake	PASS
Reconstitution clarity	reconstituted per submitter procedure	Clear, colourless, no visible particulates	—	clear, no visible particulates	PASS
pH (reconstituted, 1 mg/mL)	potentiometric, two-point calibration	5.00	—	2.5 – 8.0	PASS
Retention time (observed)	RP-HPLC, 28 min gradient	8.05	min	7.92 ± 0.25 (normalised)	PASS
Peak asymmetry (10 % height)	Ph. Eur. 2.2.46	0.98	—	0.80 – 1.50	PASS
Plate count, main peak	N = 5.54 (t/w½)²	98,586	—	≥ 20,000	PASS
Resolution to nearest impurity	vs [D-Trp]-epimer	1.07	—	no index criterion	REPORTED

Section 2

Chromatogram and peak integration

The figure is drawn from the table. It is not an independent illustration — if a number in the table changed, the trace would change with it.

Figure 1. RP-HPLC trace, 28 min gradient, 214 nm. Drawn from the peak-integration table below: peak positions are the reported retention times, peak areas are the reported area percentages, peak widths follow the reported plate count of 98,586, and skew follows the reported asymmetry factor of 0.98. Baseline noise is seeded from the report ID and is illustrative. The lower panel is the same trace at a stated vertical expansion with the slow gradient drift subtracted, because at full scale a 0.91 % impurity against a 98.57 % main peak is a line two pixels tall; the main peak runs off-scale there by design.

#	Peak	RT	Area (µV·s)	% area	Δ mass (Da)
1	GHRP-6 — main peak	8.05	4,790,808	98.57	—
2	bis-oxidised Trp (+32 Da)	7.51	44,229	0.91	+31.990
3	[D-Trp]-epimer	7.94	14,581	0.30	0.000
4	des-Lys (−128 Da)	7.84	6,318	0.13	-128.095
5	oxidised Trp (+16 Da)	7.73	4,374	0.09	+15.995
Closure check — purity + Σ impurities				100.00	CLOSES

Reporting threshold 0.05 % area. Peaks below it are not reported and are therefore excluded from the total, which overstates purity by their sum — see peak integration.

Section 3

Mass spectrum and identity

Theoretical monoisotopic mass 872.4446 Da, computed from C46H56N12O6. All ppm figures on this site are against monoisotopic values — see why that matters.

Figure 2. ESI charge-state envelope, high-resolution instrument. Sticks are placed at m/z = (M + z × 1.007276)/z for the observed neutral mass of 872.4411 Da. Sodium (+21.982/z) and potassium (+37.956/z) adducts are shown where the parent charge state exceeds 25 % relative abundance; they are adducts of the same molecule and are not impurities.

Charge	Theoretical m/z	Observed m/z	Δ m/z	Rel. abundance (%)
2+	437.2296	437.2278	-0.0018	56.1
1+	873.4519	873.4484	-0.0035	100.0

Section 4

Gravimetric mass balance

Water, counter-ion, residual and total peptide content are exhaustive and mutually exclusive categories. They must account for 100 % of the cake mass. The index closes this to within 0.02 pp and the build asserts it.

Component	Determination	%w/w of cake
Water	Karl Fischer	4.52
Counter-ion (acetate)	ion chromatography	4.69
Residual solvent + inorganic residue	estimated	0.80
Total peptide content	by difference	89.99
Total		100.00 CLOSES

Supplier certificate, as declared

The supplier's own figures for this lot, beside the independent measurement. Divergence is assessed against the batch median, not against this single report — see rule AX-R05.

Figure	Supplier COA	This report	Index note
Purity (% area)	98.79	98.57	divergence +0.18 pp vs batch median
Total impurities (% area)	1.21	1.43
Largest single impurity (% area)	not stated	0.91
Water (%)	not stated	4.52
Counter-ion (%)	7.9	4.69
Peptide content (%w/w)	88.0	89.99
Endotoxin (EU/mg)	not stated	0.46
Method stated on certificate	YES	—	column, gradient and wavelength given

Section 5

Provenance and caveats

Where a sample came from changes the weight of the evidence. The index treats it as a first-class field.

Sample provenance: Supplier-supplied
Evidentiary weight: Weaker evidence. Read with the caveat below.
Chain of custody: Supplier despatch → laboratory direct (courier, cold pack, 8 d) → assay. Submitter did not handle the vial.
Assay date: 30 May 2026
Submitted to the index: 02 Jun 2026
Laboratory: PeptideMeter, Tallinn, Estonia
Method basis: 28 min gradient · high-resolution MS
Verification status: VERIFIED

Section 6

Annotations

No annotations on this record. Annotations are short signed technical comments from index contributors; see how to contribute.

Section 7

Related records

Same batch — lot BCH-2603-Y7018 n=5

Report	Lot	Lab	Quarter	Purity %	Water %	Recovery %	Provenance	Flags	Result
AX-2026-043560	BCH-2603-Y7018	Janoshik	2026-Q2	99.25	5.25	—	Supplier-supplied	1	MARGINAL
AX-2026-043561	BCH-2603-Y7018	Janoshik	2026-Q2	98.72	5.11	99.3	Supplier-supplied	1	FAIL
AX-2026-043563	BCH-2603-Y7018	Janoshik	2026-Q2	98.61	4.05	106.7	Supplier-supplied	1	FAIL
AX-2026-043564	BCH-2603-Y7018	Medutest	2026-Q2	98.44	4.83	—	Buyer-sourced	1	FAIL

Batch rollup and reproducibility assessment →

Cross-sections

Other recent GHRP-6 records in the index.
Report	Supplier	Lot	Lab	Quarter	Purity %	Water %	Recovery %	Provenance	Flags	Result
AX-2026-042290	HJ	HJ-2603-R2258	Janoshik	2026-Q3	99.71	3.05	—	Supplier-supplied	2	MARGINAL
AX-2026-042287	HJ	HJ-2603-R2258	VendorInvestigate	2026-Q3	98.79	2.43	90.9	Buyer-sourced	2	FAIL
AX-2026-042288	HJ	HJ-2603-R2258	Kestrel	2026-Q3	99.93	2.82	92.8	Supplier-supplied	2	MARGINAL
AX-2026-042289	HJ	HJ-2603-R2258	Janoshik	2026-Q3	99.53	2.67	104.7	Supplier-supplied	2	MARGINAL
AX-2026-042291	HJ	HJ-2603-R2258	Janoshik	2026-Q3	99.60	2.94	101.3	Supplier-supplied	2	MARGINAL
AX-2026-043560	BCH	BCH-2603-Y7018	Janoshik	2026-Q2	99.25	5.25	—	Supplier-supplied	1	MARGINAL
AX-2026-043564	BCH	BCH-2603-Y7018	Medutest	2026-Q2	98.44	4.83	—	Buyer-sourced	1	FAIL
AX-2026-041615	QSC	QSC-2605-A7936	Janoshik	2026-Q2	99.93	5.30	106.1	Supplier-supplied	0	PASS

Other recent BCH records in the index.
Report	Compound	Lot	Lab	Quarter	Purity %	Water %	Recovery %	Provenance	Flags	Result
AX-2026-043574	N-Acetyl Semax Amide	BCH-2602-E8253	Janoshik	2026-Q3	97.75	8.85	97.9	Supplier-supplied	1	FAIL
AX-2026-043503	BPC-157	BCH-2603-G6422	Janoshik	2026-Q3	98.46	4.32	—	Supplier-supplied	1	MARGINAL
AX-2026-043575	N-Acetyl Semax Amide	BCH-2602-E8253	Janoshik	2026-Q3	97.44	9.19	104.8	Supplier-supplied	1	FAIL
AX-2026-043539	CJC-1295 with DAC	BCH-2607-H7307	Janoshik	2026-Q3	98.12	5.78	100.6	Supplier-supplied	1	MARGINAL
AX-2026-043504	BPC-157	BCH-2603-G6422	Janoshik	2026-Q3	98.38	4.45	95.5	Supplier-supplied	1	MARGINAL
AX-2026-043502	BPC-157	BCH-2603-G6422	PeptideMeter	2026-Q3	97.72	4.86	—	Buyer-sourced	1	FAIL
AX-2026-043501	BPC-157	BCH-2603-G6422	PeptideMeter	2026-Q3	98.37	4.75	100.8	Supplier-supplied	1	MARGINAL
AX-2026-043573	N-Acetyl Semax Amide	BCH-2602-E8253	Janoshik	2026-Q3	97.47	8.59	—	Supplier-supplied	1	FAIL