AssayIndex

SIG-2508-6459

Liraglutide · 15 mg declared · Sigma-Aldrich (Shanghai) Trading Co., Ltd. · manufactured 15 Aug 2025

CHARACTERISED
Lot code
SIG-2508-6459
Supplier
SIG — Sigma-Aldrich (Shanghai) Trading Co., Ltd.
Compound
Liraglutide
Compound class
Incretin analogues and co-agonists
Declared label claim
15mg
Manufacture date
15 Aug 2025
Index quarter
2026-Q1
Independent assays
7
Laboratories involved
VendorInvestigate, Janoshik, Medutest, PeptideMeter, Kestrel
Provenance mix
Buyer-sourced ×5 · Supplier-supplied ×1 · Laboratory-retained ×1
Section 1

Reproducibility across independent tests

Every report below is an observation of the same physical material. What they disagree about is measurement; what they agree about is the lot. The size of the disagreement is compared against what the contributing laboratories' own repeatability figures predict.

Independent assays 7
Median purity 98.48% n=7
Spread (max − min) 1.40pp n=7
Standard deviation 0.487pp n=7
96.897.397.998.599.099.6100.2This lot (SIG-2508-6459)This lot (SIG-2508-6459): Q1 98.02, median 98.48, Q3 98.64, n=7n=7All LiraglutideAll Liraglutide: Q1 98.50, median 99.00, Q3 99.34, n=88outlier 97.01outlier 97.10outlier 97.13outlier 97.20n=88 Purity (% area)
Figure 1. This lot's independent purity results against the whole Liraglutide record set in the index. The vertical line is the index acceptance specification for the incretin analogues and co-agonists class, 97.5 % area. A narrow box on the top row against a wide box on the bottom row is the ideal reading: it means the disagreement between lots is much larger than the disagreement within this one.
Section 2

Member reports 7

Every report the index holds on this lot. Each is a page carrying its own chromatogram, mass spectrum, mass balance, provenance and caveats.

ReportLotLabQuarterPurity %Water %Recovery %ProvenanceFlagsResult
AX-2026-043559SIG-2508-6459VendorInvestigate2026-Q197.665.90Buyer-sourced0PASS
AX-2026-043560SIG-2508-6459VendorInvestigate2026-Q198.484.8598.8Laboratory-retained0PASS
AX-2026-043561SIG-2508-6459Janoshik2026-Q198.145.50101.8Buyer-sourced0PASS
AX-2026-043562SIG-2508-6459Medutest2026-Q198.575.7488.6Buyer-sourced1MARGINAL
AX-2026-043563SIG-2508-6459Janoshik2026-Q198.714.9092.5Supplier-supplied1MARGINAL
AX-2026-043564SIG-2508-6459PeptideMeter2026-Q197.905.4895.6Buyer-sourced0PASS
AX-2026-043565SIG-2508-6459Kestrel2026-Q199.065.02Buyer-sourced0PASS
Section 3

By laboratory

Where more than one laboratory assayed this lot, the difference between them is a paired observation of their relative bias — the same material, the same time window, different instruments. Those pairs are what the index's bias estimates are built from.

LaboratoryReportsPurity results (% area)MedianGradientPublished bias (pp)Bias-adjusted
VendorInvestigate297.66, 98.4898.0732min-0.1198.18
Janoshik298.14, 98.7198.4230min+0.0098.42
Medutest198.5798.5725min+0.0898.49
PeptideMeter197.9097.9028min-0.0597.95
Kestrel199.0699.0615min+0.2498.82

This lot contributes 10 paired comparisons to the inter-lab analysis.

Section 4

The supplier's certificate for this lot

One number the supplier wrote, beside the median of the numbers other people measured on the same physical material. That comparison is only available because the index groups by lot.

FigureSupplier COAThis reportIndex note
Purity (% area)98.7497.66divergence +0.26 pp vs batch median
Total impurities (% area)1.262.34
Largest single impurity (% area)0.751.06
Water (%)not stated5.90
Counter-ion (%)not stated8.37
Peptide content (%w/w)not statednot determined
Endotoxin (EU/mg)not statednot determined
Method stated on certificateYEScolumn, gradient and wavelength given
Section 5

Impurity fingerprint

The named impurities reported across this lot's assays, with how consistently each was seen. A fingerprint is what allows two lot numbers held by different companies to be identified as one bulk.

Named impurityReported inMedian % areaRange
des-palmitoyl liraglutide (−238 Da)7 / 70.590.49–1.06
liraglutide dimer7 / 70.220.01–0.79
deamidated (Asn→Asp, +1 Da)7 / 70.140.08–0.26
des-His1 truncate (−137 Da)7 / 70.130.05–0.75
γ-Glu regioisomer7 / 70.040.02–0.41
palmitoyl bis-adduct (+238 Da)6 / 70.040.03–0.06
Section 7

What this rollup does not establish