AX-2026-043696

BPC-157 · 5 mg declared · Bachem Holding (Suzhou) Co., Ltd. · lot BCH-2603-L7768

FAILPURITY ONLY

Report ID: AX-2026-043696
Compound: BPC-157
Compound class: Tissue-repair and immunomodulatory peptides
Supplier: BCH — Bachem Holding (Suzhou) Co., Ltd.
Batch / lot: BCH-2603-L7768
Declared label claim: 5mg
Laboratory: Janoshik Analytical
Assay date: 08 Jul 2026
Submitted: 12 Jul 2026
Quarter: 2026-Q3
Submitter: ma.ndiaye
Sample provenance: Buyer-sourced

Section 1

Results

Measured against the index acceptance specification for the tissue-repair and immunomodulatory peptides class. A specification is a decision the index made; a result is a measurement. See where each threshold came from.

Parameter	Method	Result	Unit	Index spec
Purity	RP-HPLC, 30 min gradient, 214 nm	97.85	% area	≥ 98.0	FAIL
Total impurities	RP-HPLC, sum of reported peaks	2.15	% area	≤ 2.0	FAIL
Largest single impurity	RP-HPLC — truncated (1-12)	0.89	% area	≤ 1.00	PASS
Identity	not ordered on this submission	not determined	—	required for VERIFIED status	NOT TESTED
Peptide content	not ordered on this submission	not determined	—	required to check label claim	NOT TESTED
Water content	Karl Fischer, coulometric, duplicate	5.28	%	≤ 10.0	PASS
Counter-ion (acetate)	anion-exchange ion chromatography	6.66	%	≤ 12.0	PASS
Residual solvent + inorganic residue	estimated — see /methods/residual-solvents-q3c/	0.31	%	—	NOT TESTED
Endotoxin	not ordered on this submission	not determined	—	≤ 5.0	NOT TESTED
Sterility	not ordered on this submission	not determined	—	no growth	NOT TESTED
Appearance	visual, diffuse light, black and white background	Off-white lyophilised cake, intact	—	white to off-white intact cake	PASS
Reconstitution clarity	reconstituted per submitter procedure	Clear, colourless, no visible particulates	—	clear, no visible particulates	PASS
pH (reconstituted, 1 mg/mL)	potentiometric, two-point calibration	5.47	—	2.5 – 8.0	PASS
Retention time (observed)	RP-HPLC, 30 min gradient	9.76	min	9.62 ± 0.25 (normalised)	PASS
Peak asymmetry (10 % height)	Ph. Eur. 2.2.46	1.15	—	0.80 – 1.50	PASS
Plate count, main peak	N = 5.54 (t/w½)²	74,856	—	≥ 20,000	PASS
Resolution to nearest impurity	vs [D-Val]-diastereomer	0.96	—	no index criterion	REPORTED

Section 2

Chromatogram and peak integration

The figure is drawn from the table. It is not an independent illustration — if a number in the table changed, the trace would change with it.

Figure 1. RP-HPLC trace, 30 min gradient, 214 nm. Drawn from the peak-integration table below: peak positions are the reported retention times, peak areas are the reported area percentages, peak widths follow the reported plate count of 74,856, and skew follows the reported asymmetry factor of 1.15. Baseline noise is seeded from the report ID and is illustrative. The lower panel is the same trace at a stated vertical expansion with the slow gradient drift subtracted, because at full scale a 0.89 % impurity against a 97.85 % main peak is a line two pixels tall; the main peak runs off-scale there by design.

#	Peak	RT	Area (µV·s)	% area	Δ mass (Da)
1	BPC-157 — main peak	9.76	4,755,813	97.85	—
2	truncated (1-12)	8.80	43,257	0.89	-285.132
3	acetylated N-terminus (+42 Da)	10.24	34,994	0.72	+42.011
4	pyroglutamate cyclisation (−17 Da)	10.07	14,095	0.29	-17.027
5	[D-Val]-diastereomer	9.62	5,346	0.11	0.000
6	BPC-157 arginine-salt artefact	9.21	3,402	0.07	0.000
7	des-Gly truncate (−57 Da)	9.42	3,402	0.07	-57.021
Closure check — purity + Σ impurities				100.00	CLOSES

Reporting threshold 0.05 % area. Peaks below it are not reported and are therefore excluded from the total, which overstates purity by their sum — see peak integration.

Section 4

Gravimetric mass balance

Water, counter-ion, residual and total peptide content are exhaustive and mutually exclusive categories. They must account for 100 % of the cake mass. The index closes this to within 0.02 pp and the build asserts it.

Supplier certificate, as declared

The supplier's own figures for this lot, beside the independent measurement. Divergence is assessed against the batch median, not against this single report — see rule AX-R05.

Figure	Supplier COA	This report	Index note
Purity (% area)	97.79	97.85	divergence +0.02 pp vs batch median
Total impurities (% area)	2.21	2.15
Largest single impurity (% area)	1.37	0.89
Water (%)	not stated	5.28
Counter-ion (%)	6.2	6.66
Peptide content (%w/w)	89.7	not determined
Endotoxin (EU/mg)	not stated	not determined
Method stated on certificate	YES	—	column, gradient and wavelength given

Section 5

Provenance and caveats

Where a sample came from changes the weight of the evidence. The index treats it as a first-class field.

Sample provenance: Buyer-sourced
Evidentiary weight: Strongest available evidence in this index.
Chain of custody: Domestic warehouse despatch → submitter (2–8 °C, 10 d) → laboratory (courier, cold pack, 9 d) → assay.
Assay date: 08 Jul 2026
Submitted to the index: 12 Jul 2026
Laboratory: Janoshik Analytical, Ostrava, Czechia
Method basis: 30 min gradient · high-resolution MS
Verification status: PURITY ONLY

What this report does not establish

That the compound is the compound named. No identity confirmation was ordered on this submission. A purity figure describes chromatographic homogeneity of whatever eluted; it does not name it.
How much of the named compound is in the vial. Peptide content was not determined, so recovered mass cannot be calculated and the label claim cannot be checked.
That the material is free of bacterial endotoxin. Endotoxin was not measured. No chromatographic result bears on it.
That the material is sterile. Sterility was not tested.
That any other vial in the same lot has the same composition. One vial was tested. Within-lot vial-to-vial variation in this index has a median of 0.28 pp and a 90th percentile of 0.74 pp.
That any other lot from the same supplier has the same composition. Batch-to-batch variation is larger than within-batch variation for every supplier here.
That the material is suitable for administration to a human or an animal. These are research compounds. No result on this site is a safety assessment and the index takes no position on use.
That the material was manufactured by the supplier that sold it. Contract synthesis is normal in this market and twenty-nine batches in the index fingerprint to a bulk from a different company than the one named on the label.

Section 6

Annotations 2

Signed technical comments from index contributors. Not a discussion forum — annotations question or contextualise the result, and the data team replies where a reply is warranted.

thin_coverage12 Jul 2026

Coverage on this compound is thin enough that one record moves the class median visibly. That is a statement about the index rather than about the material, and it is why the n= badge sits beside every aggregate.

dedupe_logic12 Jul 2026

Two retail purchases of the same lot from different buyers are genuinely independent. Two aliquots of one purchase are not, and the index does not treat them as such.

Section 7

Related records

Same batch — lot BCH-2603-L7768 n=13

Report	Lot	Lab	Quarter	Purity %	Water %	Recovery %	Provenance	Flags	Result
AX-2026-043684	BCH-2603-L7768	PeptideMeter	2026-Q3	97.83	5.01	101.4	Buyer-sourced	0	FAIL
AX-2026-043685	BCH-2603-L7768	PeptideMeter	2026-Q3	97.57	5.14	—	Buyer-sourced	0	FAIL
AX-2026-043686	BCH-2603-L7768	VendorInvestigate	2026-Q3	97.64	5.27	—	Buyer-sourced	0	FAIL
AX-2026-043687	BCH-2603-L7768	Medutest	2026-Q3	98.19	5.05	103.6	Buyer-sourced	0	PASS
AX-2026-043688	BCH-2603-L7768	Janoshik	2026-Q3	97.94	5.56	—	Buyer-sourced	0	FAIL
AX-2026-043689	BCH-2603-L7768	Medutest	2026-Q3	97.77	5.06	—	Buyer-sourced	1	FAIL
AX-2026-043690	BCH-2603-L7768	PeptideMeter	2026-Q3	97.29	5.10	—	Buyer-sourced	0	FAIL
AX-2026-043691	BCH-2603-L7768	Janoshik	2026-Q3	98.66	5.12	—	Supplier-supplied	1	MARGINAL
AX-2026-043692	BCH-2603-L7768	VendorInvestigate	2026-Q3	97.60	5.61	—	Buyer-sourced	0	FAIL
AX-2026-043693	BCH-2603-L7768	PeptideMeter	2026-Q3	97.82	5.21	94.9	Buyer-sourced	0	FAIL
AX-2026-043694	BCH-2603-L7768	Kestrel	2026-Q3	97.60	5.21	—	Buyer-sourced	0	FAIL
AX-2026-043695	BCH-2603-L7768	Janoshik	2026-Q3	97.61	5.42	—	Buyer-sourced	0	FAIL

Batch rollup and reproducibility assessment →

Cross-sections

Other recent BPC-157 records in the index.
Report	Supplier	Lot	Lab	Quarter	Purity %	Water %	Recovery %	Provenance	Flags	Result
AX-2026-043691	BCH	BCH-2603-L7768	Janoshik	2026-Q3	98.66	5.12	—	Supplier-supplied	1	MARGINAL
AX-2026-043493	CPC	CPC-2602-W3201	Janoshik	2026-Q3	98.76	2.27	—	Buyer-sourced	2	FAIL
AX-2026-041387	WWB	WWB-2606-H3906	Janoshik	2026-Q3	99.33	4.64	—	Laboratory-retained	0	PASS
AX-2026-043693	BCH	BCH-2603-L7768	PeptideMeter	2026-Q3	97.82	5.21	94.9	Buyer-sourced	0	FAIL
AX-2026-043686	BCH	BCH-2603-L7768	VendorInvestigate	2026-Q3	97.64	5.27	—	Buyer-sourced	0	FAIL
AX-2026-043695	BCH	BCH-2603-L7768	Janoshik	2026-Q3	97.61	5.42	—	Buyer-sourced	0	FAIL
AX-2026-043487	CPC	CPC-2602-W3201	VendorInvestigate	2026-Q3	99.07	2.76	97.0	Laboratory-retained	1	MARGINAL
AX-2026-041385	WWB	WWB-2606-H3906	Medutest	2026-Q3	99.29	4.43	—	Buyer-sourced	0	PASS

Other recent BCH records in the index.
Report	Compound	Lot	Lab	Quarter	Purity %	Water %	Recovery %	Provenance	Flags	Result
AX-2026-043691	BPC-157	BCH-2603-L7768	Janoshik	2026-Q3	98.66	5.12	—	Supplier-supplied	1	MARGINAL
AX-2026-043693	BPC-157	BCH-2603-L7768	PeptideMeter	2026-Q3	97.82	5.21	94.9	Buyer-sourced	0	FAIL
AX-2026-043686	BPC-157	BCH-2603-L7768	VendorInvestigate	2026-Q3	97.64	5.27	—	Buyer-sourced	0	FAIL
AX-2026-043695	BPC-157	BCH-2603-L7768	Janoshik	2026-Q3	97.61	5.42	—	Buyer-sourced	0	FAIL
AX-2026-043726	N-Acetyl Semax Amide	BCH-2602-E8475	Janoshik	2026-Q3	97.89	9.67	104.2	Buyer-sourced	0	FAIL
AX-2026-043688	BPC-157	BCH-2603-L7768	Janoshik	2026-Q3	97.94	5.56	—	Buyer-sourced	0	FAIL
AX-2026-043658	BPC-157	BCH-2603-G6644	Janoshik	2026-Q3	98.45	4.37	101.8	Supplier-supplied	0	PASS
AX-2026-043692	BPC-157	BCH-2603-L7768	VendorInvestigate	2026-Q3	97.60	5.61	—	Buyer-sourced	0	FAIL