AssayIndex
Mass spectrometry

Ion suppression

Reduction in analyte ionisation caused by a co-eluting species or a mobile-phase additive. Trifluoroacetic acid is a strong suppressor.

Related terms

Trifluoroacetic acid (TFA)
Mobile-phase additive at 0.1 %. Gives excellent peptide peak shape and suppresses electrospray ionisation. Also the most common peptide counter-ion.

Where this term appears

The glossary exists to make record pages readable without a chemistry degree. Every technical term on a report resolves here.