Trifluoroacetic acid (TFA)
Mobile-phase additive at 0.1 %. Gives excellent peptide peak shape and suppresses electrospray ionisation. Also the most common peptide counter-ion.
Related terms
- Counter-ion
- The anion paired with a peptide's basic residues in the isolated salt. Usually trifluoroacetate or acetate. Mass in the vial that is not peptide.
- Ion suppression
- Reduction in analyte ionisation caused by a co-eluting species or a mobile-phase additive. Trifluoroacetic acid is a strong suppressor.
see also Trifluoroacetic acid (TFA) · Salt form
see also Trifluoroacetic acid (TFA)
Where this term appears
The glossary exists to make record pages readable without a chemistry degree. Every technical term on a report resolves here.
- Assay report records — the term appears in result tables, peak tables and provenance blocks
- Method references — where the measurement behind the term is defined
- All 10 glossary terms beginning with T