AssayIndex
Impurities & degradation

Pyroglutamate

Cyclisation of an N-terminal glutamine or glutamate, −17.027 or −18.011 Da. Also the native N-terminus of GnRH, where acid stress opens it to +18.011.

Related terms

Diketopiperazine
A cyclic dipeptide, −18.011 Da, formed by intramolecular attack at the N-terminus. Common in proline-rich short peptides.
see also Pyroglutamate

Where this term appears

The glossary exists to make record pages readable without a chemistry degree. Every technical term on a report resolves here.